The environmental and economic concern is the biggest challenge concrete industry is facing. Advancement in utilization of wastes in concrete as a mixture reduces pollutants in environment and maximizes usage of natural resources( Shreekantet al., 2016). During the production of cement CO2 is produced from clinkerizationwhich causes global warming (Andrew, 2018). By reducing clinker consumption environment can be protected(https://www.wbcsdcement.org). An attempt was made to partially replace the clinker with waste material Quarry dust with an aim not to lose the strength far from original concrete mix. From the observations of test results, clinker can be replaced with 15% of quarry dust in concrete. The physical and mechanical properties of materials used in concrete were investigated. For each replacement cubes were casted for measuring 7days and 28days compressive strength. The results have been discussed. Here mine’s screen reject is used for partial replacement of clinker in cement manufacturing for studying the strength property of concrete. The aim of the experiment is to find the maximum content of mine’s screen reject partial replacement of clinker without compromising with the quality and strength of concrete.