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Human leukocytes antigens hladqb1 determine susceptibility to thyroid disease in sample of patients

Author: 
Tawfeeq Jasim Mohammad, Dr. Mohammad Al-Kurtas, Dr. Haider Hashim Zalzala, Dr. Batool Mutar Mahdi, Dr. Hyam Raouf, Laheeb Ali Abid and Zena Nehad
Subject Area: 
Health Sciences
Abstract: 

Background: Thyroid disease is a common prevalent disease in the women of reproductive age. This disease arises due to complex interactions between environmental and genetic factors. On the other hand, the relations between genes and environment are yet to be identified. The most important susceptibility genes that have been identified is the HLA-DQB1 gene locus on chromosome number six. The major environmental factors include iodine, medications, infection, smoking, and possibly stress. Aim of study: the association between HLA-DQB1 alleles and goitrous thyroid disease in a group of Iraqi Arab Muslims. Patients and methods: A case-control comparative research was carried out in Al-Kindy Teaching Hospital, Baghdad-Iraq. Patients with thyroid diseases attended this hospital in the period September-2013 to June-2014 for thyoidectomy. HLA –DQB1genotyping was done using a group of sequence-specific oligonucleotide probes (SSOP) method by means of HLA-DQB1amplification kit and other hybridization kit (SSO HLA type DQB1 plus and Mastermix for HLA type DQB1 Amp plus kits -Innogenetics- from Belgium) by using AutoLipa – 48Innogenetics-Belgum. Results: There was an increased frequency of HLADQB1*03:01and 0601 in control group compared with patients group (P=0.005, Odds ratio=0.0164, 95% Confidence Interval: 0.0009-0.2926) and (P=0.01, Odd ratio=0.1667, 95% Confidence Interval: 0.0412 to 0.6750) respectively. Other alleles like HLA-DQB1* 0202, 03:02, 0501 and 06:02 were detected in patients group and not in control group. Conclusions: HLA alleles have an effect on development thyroid disease. HLADQB1* 0301 and 0601 is a protective in Iraqi Arab Muslims individuals.

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