CALL FOR PAPERS

Author Information

CERTIFICATE

IMPACT FACTOR 2019

Subject Area

Life Sciences / Biology
Architecture / Building Management
Asian Studies
Business & Management
Chemistry
Computer Science
Economics & Finance
Engineering / Acoustics
Environmental Science
Agricultural Sciences
Pharmaceutical Sciences
General Sciences
Materials Science
Mathematics
Medicine
Nanotechnology & Nanoscience
Nonlinear Science
Chaos & Dynamical Systems
Physics
Social Sciences & Humanities

Why Us? >>

Open Access
Peer Reviewed
Rapid Publication
Life time hosting
Free promotion service
Free indexing service
More citations
Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Large scale synthesis of high purity iopamidol

Author:

Kesamreddy Ranga Reddy, Emani Vijayabhaskar Reddy, Lingareddy Sunil and J.V. Shanmukha Kumar

Subject Area:

Physical Sciences and Engineering

Abstract:

A commercial scale synthesis of ultra-pure Iopamidol 1 has been achieved using a simple protocol employing with a total of 9 steps and easily isolatable intermediates. The key intermediate (S)-1-((3,5-bis-(chlorocarbonyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate 7 has been synthesized with high purity. The main advantages of the route include readily available inexpensive starting materials and good overall yield of 78%. The process impurities including chiral analogue have been well controlled without using any resins or chiral separation techniques but with simple chromatographic grade silica treatment. The structures of all intermediates prepared were confirmed by NMR, IR and MS and HPLC analysis.

PDF file:

30087.pdf

Announcement

QUICK RESPONSE - CONTACT US

Please feel free to contact me if you have any questions or comments....

Invited for research articles

Call for papers -May 2022

Call for Editorial Board Members

We are seeking professionals to join our Editorial Board. You will be entitled following benefits while...