CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Letrozole indifferent dosages for ovulation induction in patients with polycystic ovarian syndrome not responded to clomiphene citrate

Author: 
ZakariaMahdyMorsy Nada (MD) and Muhammed Sayed Ahmed Emarah (MD)
Subject Area: 
Health Sciences
Abstract: 

Objective: To choose the suitable dose of letrozole (LTZ) for ovulation induction in anovulatory patients with polycystic ovarian syndrome (PCOS). Design: Prospective randomized study. Setting: OB/GYN department, Benha Teaching Hospital, Benha, Egypt. Patient(s): 120 anovulatory infertile women with PCOSthatwerenot responded to clomiphene citrate(CC) stimulation for one cycle. Intervention(s): The studied patients were randomly divided into 3 groups (A, B, C). LTZ was given in increasing dosage from group "A" to group "C". Materials and Methods: In group "A": the dose of letrozolewas 2.5 mg / day, in group "B": it was 5 mg / day, and in group "C": it was 7.5 mg per day. The LTZ was given from day 2-6 of the menstrual cycle. Main outcome measures were: ovulation rate, number of mature follicles, endometrial thickness and pregnancy rate. Results: On increasing the LTZ dosages between the three groups (A, B and C),only the mean number of dominant follicles and the numbers of ovulatory cycles were significantly increasing; (P=0.025) and (P=0.012), respectively. On the other hand, the relation was insignificant for mid-cycle endometrial thickness and the pregnancy rate; (P=0.542) and (P=0.765), respectively.The differences in the age, duration of infertility and body mass index (BMI) were not statistically significant between the three groups. Conclusion:Letrozole is superior to CC in ovulation induction for patients with PCOS. Increasing the letrozole dosage will increase the number of mature follicles and ovulation rate, but has no effect on pregnancy rate.Until studies with large sample sizes are available, LTZ may be used as the first or second option for ovulation induction and to start with 2.5 mg per day and increase the dose gradually in the subsequent cycles if there is no adequate response.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran