CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Occult neuroendocrine differentiation in non-small cell lung carcinoma

Author: 
Datar, R. A., Sahu, K. K. and Pai, R. R
Subject Area: 
Health Sciences
Abstract: 

Introduction: Neuroendocrine (NE) differentiation can be documented by immunohistochemistry (IHC) with the use of synaptophysin (SYN) and chromogranin (CGA) in some lung carcinomas with conventional non-small cell morphology. These tumors are referred as non-small cell lung carcinomas with neuroendocrine differentiation (NSCLC-ND) or non-small cell lung carcinoma with occult neuroendocrine differentiation. The finding of NE differentiation in some NSCLC has led to the hypothesis that these tumors may form a subgroup with a prognosis and response to treatment between NSCLC and SCLC. (Pelosi et al., 2003; Wick et al., 2011; Howe et al., 2005) Aim: To find occult NE differentiation in NSCLC using CGA and SYN. Materials and Methods: The IHC markers, CGA and SYN were done on 37 NSCLC cases which compromised of 23 Squamous cell carcinomas (SCC) and 14 adenocarcinomas. Semiquantitative assessments of staining intensity and percentage of tumour cells positive were made. An Intensity Distribution (ID) score of > 1 with any marker was used as the criterion for evidenceof NE differentiation. Results: NE differentiation was seen in 40.54% of NSCLC. 50% of adenocarcinomas and 34.8% SCC showed NE differentiation. SYN and CGA positivity was seen in 29.7% and 24% NSCLCs respectively. Adenocarcinoma showed significant immunoreactivity for SYN (p=0.042) while SCC showed significant immunoreactivity for CGA (p=0.035) Conclusion: In our study, 40.5% of NSCLC showed NE differentiation. NE differentiation was seen more in adenocarcinoma than in SCC. Synaptophysin showed significant association with adenocarcinomas and chromogranin with SCC.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran