Dental caries is a pathological process of localized destruction of tooth tissue by micro-organisms. The disease is initiated via, demineralization of tooth hard tissue by organic acids produced from fermentable carbohydrates by dental plaque and cariogenic bacteria. One of the most important concepts in the field of saving tooth structure is remineralization. Fluoride ions can drive the remineralization of previously demineralized enamel in the presence of salivary or plaque calcium, phosphate ions. Thus, this review aims with the non-invasive treatment of early carious lesions by potential remineralizing agents that has been a major advance in the clinical management of the disease.