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Preparation of a local anti-wart and anti-inflammatory rub of hydroxy propyl methyl cellulose and polyglycidol based saturated lipid, di-dodecyl oxypropane-2-polyglycidol containing curcumin as dermal medicament

Author: 
Sharif M Shaheen, Pavel Bakardzhiev, Denitsa Momekova and Stanislav Rangelov
Subject Area: 
Health Sciences
Abstract: 

Background: Curcumin is a non-toxic neutracical, which possesses/exhibits an antioxidant activity and inhibits intracellular factors such as Nf-B, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS). However, it is poorly absorbed and has a limited bioavailability. If curcumin could be delivered directly into the cell, it might be a potential therapeutic agent. Objective: The aim is to prepare a medicament to deliver curcumin directly through the cutaneous membrane and to find out the potentiality as a topical therapeutic. Method: We synthesized a polyglycidol-derived lipid, DDP-PG (Mw = 2650), which was incorporated into hydroxypropyl methyl cellulose, HPMC (7%), to prepare a rub containing curcumin. Another formulation containing monoolein rac glycerol, MO (a reported skin penetration enhancer) with DDP-PG was incorporated as a control. Subsequently, curcumin-containing DDP-PG was evaluated directly for therapeutic purposes treating local apoptotic skin, inflammatory site and benign tumor mass (wart). Results: The diffusion of curcumin was evaluated in vitro using a biomembrane (fish swim bladder). The diffusion of curcumin form DDP-PG based formulations did not differ from that of MO, which indicated their suitability as a transdermal vehicle. Accordingly, after application in a few dermal disorders, it showed skin cured very promisingly from apoptotic keratinocytes, clearing the inflammation perfectly and dramatically reduced the size of the wart (a benign tumor) as well. Conclusion: Curcumin can be delivered directly with a du novo skin penetration enhancer, DDP-PG in HPMC based rub. A “Bench to Bed Technology” was approached for controlling local inflammation, apoptotic keratinocytes, and benign tumor like wart, studied here.

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