In this study attempts have been made to find out the correlation and variation of the major disease problems encountered in carp culture sectors with the physicochemical characteristics of the important cultural areas of West Bengal. Water quality parameters such as temperature, pH, dissolved oxygen, free CO2, total alkalinity, transparency and hardness were analyzed during the investigation. The recorded sampling values of these variables were correlated with diseases noticed. Most of the parameters were found to be significant at 5 % level and few are significant at 1 % level whereas only the temperature was found to be significantly varied at 0.01% level indicatinges the importance of these is parameter in disease development. The above variables were found to have a definite impact individually or as a whole on the prevalence of diseases at different locations. However, among these water quality parameters transparency, DO, total alkalinity and hardness were found to be significantly varied with locations at 0.01% level due to the change in the culture regime and management practices undertaken.