Primary adrenal lymphoma b a large cells (about twocases)

Bilateralprimary non-Hodgkin’slymphoma (NHL) of the adrenals is uncommon. 136 cases have been described in the literature. The symptoms of disease are variable and depend on the tumor size and the presence of adrenal insufficiency we report 2 cases of adrenal lymphoma, discovered following bilateral back pain and deterioration of general conditions. Hormonal exploration demonstrated adrenal insufficiency. Imaging explorations showed a large and bilateral adrenal mass. Percutaneous ultrasound guided biopsy of the adrenal and search for extension revealed primary bilateral adrenal lymphoma. After glucocorticoid substitution, treatment was based on a CHOP regimen chemotherapy, our two patients died uring their first year of treatment. The diagnosis of primary adrenal non-Hodgkin lymphoma should be investigated in patients with a rapidly growing bilateral adrenal mass associated with adrenal insufficiency.