Primary cutaneous CD30- positive large cell lymphoma (CD30+ PCLCL) represents a spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end, and primary cutaneous anaplastic large cell lymphoma (PCALCL) at the other. We present two cases of CD30+PCLCL. First case presented with papules and nodules with severe itching. Biopsy of the skin showed atypical multinucleate RS like cells. Second patient had a history of ulcerated plaques and papules over scalp, back and thigh which showed many atypical cells. Atypical cells in both cases stained positive for CD30, CD3 and CD4 and negative for ALK, EMA. After a thorough clinicopathological correlation a diagnosis of CD30+PCLCL – lymphomatoid papulosis was made in first case and CD30+ PCLTCL – Anaplastic type in second. CD30+ PCLCL are characterized by an excellent prognosis. Therefore, it is essential to consider other differentials before making a final diagnosis.
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