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A Prospective Study Of Extent Of Hepatic Involvement In Patients Of Dengue Infection Presenting At A Tertiary Care Hospital In Rohilkhand Region

Author: 
Mowar, A. B., Himanshu, V., Smita, G., Mirinda, J. and Ashita, M.
Subject Area: 
Health Sciences
Abstract: 

Dengue is one of the most commonly occurring epidemic, particularly in rohilkhand region of Uttar Pradesh. The clinical manifestation ranges from being asymptomatic (in upto 80% patients) to mild illness (fever, thrombocytopenia, hepatic/renal dysfunction) to severe form (DHF/DSS – dengue haemorrhagic syndrome/dengue shock syndrome, DIC, MODS). Also it has been observed that the clinical and biochemical profile of dengue infection varies from epidemic to epidemic. We in this prospective study aim to study the epidemiological pattern, clinical profile and incidence and extent of hepatic complications in cases of Dengue fever in patients admitted at SRMS-IMS, Bareilly. We found that males were predominantly affected (73.3%). Most patients belonged to 15-45yr age group (85.5%). The incidence of DF, DHF, DSS were 64.4%, 26.7% and 8.9% respectively. Fever (100%) followed by headache (68.8%) was most common symptom. Malena (17.8%) followed by petechial rash (12.2%) and hematuria (3.3%) was most common hemorrhagic manifestation. Thrombocytopenia (platelet < 1lac/mm3) was present in 79% of patients. IgM antibody positive was seen in 40% patients and IgM was weekly positive in 15.5% patients. Raised bilirubin was present in 28.9% patients. Raised SGOT, raised SGPT, raised PT and raised APTT was present in 62.2%, 68.9%, 83.4% and 90% patients respectively. The most common finding on abdominal ultrasonography was ascitis (24.4%) followed by pleural effusion (18.9%), splenomegaly (14.4%) and hepatomegaly (6.6%).

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