Background: We present the study of development of trigger finger in post Carpal Tunnel Syndrome release patients with diabetes mellitus hypothroidism as risk factors. Patient and Methods: 103 patients with Carpal Tunnel Syndrome in age group 45-55 with no trigger finger prior to surgery selected, underwent Carpal Tunnel Syndrome release and followed up for 3-5 months and developed triggering of the finger. Results: All patients are selected with Carpal Tunnel Syndrome with no prior trigger finger underwent Carpal Tunnel Syndrome release by Mini Palm Carpal Tunnel release technique and most the patients developed have diabetes mellitus as the main risk factor. Conclusion: Diabetes Mellitus is a major contributing factor in patients developing triggering of the finger in the post carpal tunnel syndrome release hand.