The devastating morbidity and mortality caused by SARS COV-2 pandemic led to spurred research for development of vaccines against the SARS-CoV2 virus. Usually, the development of a new vaccine takes 10–15 years, but the search for a vaccine against SARS-CoV2 moved at a breakneck speed, with numerous research institutions and vaccine producers nearing a breakthrough in vaccine development within 15-18 months. At present numerous vaccines are available but vaccines do not confer 100% immunity. Emerging new variants are a constant worry about breakthrough infections globally. However, there isn't enough data to state whether insufficient vaccine-induced immunogenicity caused breakthrough infections during the variant's outbreak. There are concerns regarding the occurrence of breakthrough infections after vaccination, and it is still a topic of exploration.
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