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A study of adverse drug reactions in tuberculosis patients due to directly observed treatment therapy at government hospital in the city of warangal, Telangana, India

Author: 
Rashmi Pusunoori, Manjari Bodasu, Spandana Adepu and Sangram Vurumadla
Subject Area: 
Health Sciences
Abstract: 

Background: As with the profile of adverse drug reactions (ADRs) due to directly observe treatment, short course (DOTS), there is no report available in patients receiving anti tuberculosis (antiTB) chemotherapy in Warangal region, Telangana, India. One of the main reasons for non-adherence to antiTB therapy (ATT) is adverse drug reactions (ADRs), even under DOTS. Objective: This main objective of the study was to determine the incidence and prognosis of ADRs due to DOTS therapy, and to evaluate their impact on anti-TB treatment in Warangal district, Telangana State. Methods: A prospective population-based study was performed from January 2014-August 2014. Sputum smear positive pulmonary tuberculosis patients who received DOTS therapy were included and followed up for six months. The suspected ADRs were recorded. Results: A total of 120 Tuberculosis patients were included in this study. 70 patients (58.3%) showed at least one ADR due to anti tubercular regimens. The incidence (count) of ADR based on affected organ was: gastrointestinal disorders in 35 patients (41.17%), anemia in 30 patients (42.85%), ototoxicity and giddiness in 19 patients (27.14%), Liver dysfunction in 17 patients (24.28%), allergic reactions in 12 patients (17.14%), Muscle weakness in 11 patients (12.94%). No ADRs were observed in CVS. Most cases of ADRs (53%) had a good clinical outcome. Conclusions: The incidence of ADRs due to DOTS therapy was 58.3%. These ADRs had a substantial impact on TB control in Warangal. This highlighted the importance of developing strategies to ameliorate ADRs both to improve the quality of patient care and to control TB safely.

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