To study the clinico-haematological spectrum of pancytopenia in a tertiary care centre of north india

The present prospective cross sectional study was conducted at Pt. B.D. Sharma PGIMS Rohtak, Haryana on 100 patients of pancytopenia of age group 14-65 years coming to OPD and admitted in hematology and medicine ward during year 2012-2013, over a period of 1 year. The patients were properly evaluated for their complete clinical profile & etiology of pancytopenia. Panctopenia was diagnosed in the presence of hemoglobin <12gm/dl, total leukocyte count (TLC) <4000/microL, platelet count <1,00,000/microL. Thorough relevant investigations were carried out. Most patients belong to young age group with mean age 42.87±15.54 years. Most common etiology of pancytopenia was megaloblastic anemia (39%) followed by aplastic anemia (29%), Aleukemic leukemia (15%) and other causes. Among megaloblastic anemia pure vitamin B12 deficiency was observed in 27 cases. On clinical examination pallor was present in 100% cases. 31% of patients had hepatomegaly, 27% of patients had splenomegaly. We compared the results of our study with other studies & concluded that clinico-hematological spectrum of pancytopenia varies from region to region.