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Synthesis and antimicrobial evaluation of methylene-based thiazolidinone derivatives

Author:

Divyanshu D. Patel, Keshav C. Patel and Paresh S. Patel

Subject Area:

Physical Sciences and Engineering

Abstract:

Thiazolidinone derivatives have been synthesized by reacting various Schiff base with thioglycolic acid by using catalyst ZnCl2 in 1,4-dioxane at room temperature. The structure of title compounds were established by elemental, IR and 1H NMR spectral data. All the synthesized compounds were screened for in vitro antibacterial and antifungal activities on E. coli, P. aeruginosa, S. aureus, S. pyogenes, C. albicans, S. cervecieaceae and A. clavatus.

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