Synthesis and antimicrobial evaluation of Pyranopyrazole based Tetrazoles using glycerol as green solvent

Pyranopyrazoles are valuable heterocyclic compounds in which pyran and pyrazole moiety coexist in same molecule. Pyranopyrazole derivatives are significant pharmacophores which are associated with broad range of biological applications. Pyrano(2,3‐c) pyrazole derivatives show many bioactivities such as antimicrobial, insecticidal, anti‐inflammatory activities and molluscicidal activity. But the production of such molecules required harsh reaction conditions and costly catalyst. So, in the present world reactions mediated with green protocols always attract much attention. In this report we synthesize some pyranopyrazole based tetrazoles using glycerol as clean and green solvent. The targeted compounds were evaluated for their anti-microbial activity and it was observed that pyranopyrazoles linked with tetrazoles exhibit potent antibacterial activity as compared to their starting analogues.